Prevention of Alzheimer’s Disease

Scientists have learned that a build-up of amyloid plaque in the brain can contribute to the gradual destruction of brain cells and worsening memory loss in Alzheimer’s disease. Doctors at NCR are conducting a study for adults who currently have no memory loss symptoms but may be at high risk of developing Alzheimer’s Disease due to a buildup of amyloid plaque on the brain.

The study will evaluate a medication which removes this amyloid plaque to see if the onset of memory loss due to Alzheimer’s disease can be prevented or slowed. The study provides a complete medical evaluation (at no cost to the volunteer) including memory testing, a MRI evaluation, and a PET scan (to see if there is any amyloid plaque in the brain).

The study will continue for 4 years with routine visits throughout this time to receive medication and undergo further testing.

55 years or older

• Be 55 to 80 years old
• If 55 to 65, the patient must have a first degree relative with a diagnosis of Alzheimer’s Disease, or have a positive ApoE4, or have confirmed amyloid plaque in their brain.
• Has no evidence of memory loss on testing
• Has a person who could serve as a study partner by having at least weekly contract with the participant.
• Has no history of strokes or seizures
• Has had no major psychiatric disease in the past 2 yrs.
• Is able to undergo an MRI (i.e. has no metal in their body which prohibits this scan).

• Complete up to 5 visits over 90 days to determine whether the individual qualifies to participate in the study. This will include having a PET brain scan conducted to determine whether amyloid plaque is present.
• Once qualified, the participant will return to the research center every two weeks to receive study medication for 18 months and thereafter once monthly for 30 months.

You will be reimbursed for your participation.